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GENERATION OF
PROBIOTICS

NATURAL PRODUCT

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DISCOVER THE
DIFFERENCE
Clinical studies have confirmed the positive effects of probiotics on the skin. There is a “gut-skin” axis, thanks to which probiotic bacteria from the intestine have a beneficial effect on the skin (1).

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4TH GENERATION
PROBIOTICS

The development of next-generation probiotic cultures is the result of many years of research that systematically focused on the chain of processes inside the organism.

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DISCOVERY OF
THE FLAVOBIOTIC
DIFFERENCE

NYADERM® ProBio contains a concentrated mixture of polyphenols, so-called flavobiotics from olives, pomegranate, grapefruit, orange, blueberries and green tea.

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PROBIOTICS FOR THE DEMANDING

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WHAT ARE 4TH GENERATION PROBIOTICS?

4th generation probiotics bring a pure LIVE bacterial culture in the form of a biofilm, the presence of which is important for the adhesion of bacteria to the intestinal epithelium. Their structure is close to the real state in which they occur on the intestinal mucosa. They have optimized conditions for fast adhesion to the intestinal epithelium, are characterized by higher stability and higher resistance to the acidic pH of the stomach.

WHAT ARE FLAVOBIOTICS?

Flavobiotic: a preparation containing plant flavonoids that has a beneficial effect on the growth and reproduction of friendly intestinal bacteria. 

In addition, the flavobiotic-flavonoids are converted by intestinal bacteria into other molecules that act, for example, as super antioxidants and very strong anti-inflammatory substances. Their effect is therefore not only prebiotic, but extends to a systemic beneficial effect for the entire body (cardiovascular system, skin, etc.)

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EXPERT OPINION

RNDr. Petr Ryšávka, Ph.D.

Human aging and an increase in the risk of death are fundamentally determined by intestinal bacteria. Their composition changes quite significantly during life. E.g. infants usually have up to ninety percent of bifidobacteria in their intestines, which are often referred to as the “bacteria of eternal youth”, but in a seventy-year-old person, their amount is reduced to only thousandths of a percent.”

Aesthetic problems: reduced firmness, elasticity, skin and complexion hydration, sagging skin due to cellulite.

Probiotic bacteria ensure the production of a whole range of metabolites that enter the bloodstream and are important molecules for skin regeneration. These molecules include, for example, short-chain fatty acids (1).

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Health problems: acne, eczema, pigmentation, spots on the skin and complexion. When inflammatory conditions occur, a number of studies have confirmed that the modulation of intestinal immunity also leads to the modulation of immune reactions on the skin. This has a huge impact, especially in the case of eczema and atopic dermatitis. Both of these diseases are caused by the “disruption” of the immune system. We can “bring it back to normal” with the help of probiotics and regulation of immunity from the intestine (1).
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Use of antibiotics: Antibiotics are substances that inhibit (stop) the growth and reproduction of microorganisms or kill them.

The biological effects of antibiotics are caused by a change in the natural bacterial microflora of the skin or mucous membranes. They are particularly common when using broad-spectrum antibiotics (ampicillin, tetracyclines) (6). Broad-spectrum antibiotics are a unique medicine, but also a “poison” because they eradicate harmful bacteria as well as beneficial bacteria. As a result, the delicate balance of the bacterial population inside the body and on the skin is disturbed. Each course of treatment with broad-spectrum antibiotics affects the gut microbiome for up to two years (7).

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REASONS WHY TO USE NYADERM PROBIO?

Immune problems: bacterial, fungal, yeast and viral infections.

Administering probiotics will gently and naturally help to activate the defence mechanisms on the skin, which will limit the occurrence of bacterial and yeast infections (1).

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HOW LONG TO USE
NYADERM® PROBIO?
The duration of the NYADERM® ProBio treatment depends on what problems you need to solve with its help.

3

AESTHETIC PROBLEMS

I recommend taking for a minimum of 3 months(1).
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6

HEALTH PROBLEMS

I recommend long-term use for 5-6 months. Probiotics are completely safe and taking them is like eating yogurt(1).
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2

IMMUNE PROBLEMS AND ANTIBIOTIC USE

I recommend taking for a minimum of 1 – 2 months(1).
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WHY WAS NYADERM® PROBIO DEVELOPED?

NYADERM® ProBio was developed primarily from the desire to help people improve their lives. Thanks to the balanced ratio of live cultures, vitamins, prebiotics and flavobiotics, of which there are 10 billion in one capsule, they are an ideal dietary supplement for those people with skin problems. On the basis of clinical studies, it was possible to verify the fact that there is a “gut-skin” axis(1) , thanks to which these probiotic bacteria have a beneficial effect on the skin. By regularly using NYADERM® ProBio, you can get rid of acne, eczema or pimple problems for good and enjoy life with 100% firm and hydrated skin.

STUDIES AND CITATIONS

All studies and citations referenced.
Studies and citations

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The unique combination of ingredients in NYADERM® Anti-aging Drink addresses a broader spectrum of problems.

NYADERM® Probio

is a unique dietary supplement containing an optimised combination of clinically tested 4th generation probiotics, prebiotics, flavobiotics, riboflavin and biotin.

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DISCOVER THE
DIFFERENCE
Clinical studies have confirmed the positive effects of probiotics on the skin. There is a “gut-skin” axis, thanks to which probiotic bacteria from the intestine have a beneficial effect on the skin (1).

The advantages of probiotics are also that they can restore hydration processes in the skin in a natural way. By using them regularly, you will improve the quality of your skin, as probiotics balance the pH of the skin and support the cleansing processes in the pores. They also deal with pimples, eczema, acne and protect hypersensitive skin. Appropriately selected probiotics also prevent the formation of premature wrinkles and thus generally slow down the aging of the skin.

DISCOVER THE DIFFERENCE
Clinical studies have confirmed the positive effects of probiotics on the skin. There is a “gut-skin” axis, thanks to which probiotic bacteria from the intestine have a beneficial effect on the skin (1).

The advantages of probiotics are also that they can restore hydration processes in the skin in a natural way. By using them regularly, you will improve the quality of your skin, as probiotics balance the pH of the skin and support the cleansing processes in the pores. They also deal with pimples, eczema, acne and protect hypersensitive skin. Appropriately selected probiotics also prevent the formation of premature wrinkles and thus generally slow down the aging of the skin.

4TH GENERATION
PROBIOTICS

The development of next-generation probiotic cultures is the result of many years of research that systematically focused on the chain of processes inside the organism.

4th generation probiotics bring a pure bacterial culture in the form of a biofilm, the presence of which is important for the adhesion of bacteria to the intestinal epithelium. A continuous layer of biofilm bacteria creates a protective and stimulating barrier that is more stable and resistant to the acidic pH of the stomach(2). Thus, the biofilm in the digestive tract provides effective protection of the skin’s beneficial bacteria from destruction.
4TH GENERATION PROBIOTICS

The development of next-generation probiotic cultures is the result of many years of research that systematically focused on the chain of processes inside the organism.

4th generation probiotics bring a pure bacterial culture in the form of a biofilm, the presence of which is important for the adhesion of bacteria to the intestinal epithelium. A continuous layer of biofilm bacteria creates a protective and stimulating barrier that is more stable and resistant to the acidic pH of the stomach(2). Thus, the biofilm in the digestive tract provides effective protection of the skin’s beneficial bacteria from destruction.
DISCOVERY OF THE FLAVOBIOTIC DIFFERENCE

NYADERM® ProBio contains a concentrated mixture of polyphenols, so-called flavobiotics from olives, pomegranate, grapefruit, orange, blueberries and green tea.

The amount of polyphenols used covers half a day’s serving of fruit and vegetables.  Plant polyphenols have extraordinary antioxidant properties, which have a beneficial effect against the signs of aging (3).At the same time, they act as a prebiotic that stimulates a healthy gut microbiome. They also affect the cardiovascular system, including blood vessels, thus contributing fundamentally to maintaining healthy blood circulation in the skin. Thanks to this, its strength, elasticity and hydration are maintained(1). Clinical studies have shown that, for example, the polyphenols contained in pomegranate have a photoprotective effect and help the skin cope with damage from UV radiation (4). In addition, they reduce the loss of collagen, reduce the breakdown of skin proteins, and thanks to them, the skin is better able to maintain its elasticity and youthful appearance (5).
DISCOVERY OF THE FLAVOBIOTIC DIFFERENCE

NYADERM® ProBio contains a concentrated mixture of polyphenols, so-called flavobiotics from olives, pomegranate, grapefruit, orange, blueberries and green tea.

The amount of polyphenols used covers half a day’s serving of fruit and vegetables.  Plant polyphenols have extraordinary antioxidant properties, which have a beneficial effect against the signs of aging (3).At the same time, they act as a prebiotic that stimulates a healthy gut microbiome. They also affect the cardiovascular system, including blood vessels, thus contributing fundamentally to maintaining healthy blood circulation in the skin. Thanks to this, its strength, elasticity and hydration are maintained(3). Clinical studies have shown that, for example, the polyphenols contained in pomegranate have a photoprotective effect and help the skin cope with damage from UV radiation (3). In addition, they reduce the loss of collagen, reduce the breakdown of skin proteins, and thanks to them, the skin is better able to maintain its elasticity and youthful appearance (3).
Studies and citations
1. RNDr. Petr Ryšávka, Ph.D., molecular biologist and probiotics expert
2. PROBIOTIC BIOFILM ON CARRIER SURFACE: A NOVEL PROMISING APPLICATION FOR FOOD INDUSTRY, M. GROSSOVA*, P. RYSAVKA and I. MAROVA, Faculty of Chemistry, Department of Food Chemistry and Biotechnology, Brno University of Technology, Purkynova 118, CZ-61200 Brno. Czech Republic, 2017
3. Manach,C., Scalbert,A., Morand, C. 2004, Polyphenols: Food Sources and Biovailability, American Journal of Cilinical Nutrition, 79(5), 5.2004, s.727-47. Available at: https://academic.oup.com/ajcn/article/79/5/727/4690182
4. Afaq,, F., Katiyar, S.K.2011, Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis. Mini-Reviews in Medicinal Chemistry, 11(14), December 2011, s.1200-1215. Available at: https://www.nebi.nlm.nih.gov/pubmed/22070679.
5. Afaq, F., Zaid, M. A. Khan, N., a kol.2009. Protective Effect of Pomegranate-Derived Products on UVB-Mediated Damage in Human Reconstituted Skin. Experimental Dermatology, 18(6), June 2009, s. 553-61. Available at: https://www.nebi.nlm.nih.gov/pubmed/19320737
6. Source: Antibiotics – WikiSkripta
7. Steven R. Gundry, the Longevity Paradox – How to Die Young at a Ripe Old Age, HarperCollins Publishers, USA, 2019
8. Akst, J.2014 Microbes of the Skin. The Scientist, 13.6.2014
9. University of California – San Diego.2018. Beneficial Skin Bacteria Protect Against Skin center. ScienceDaily
Studies and citations
1. RNDr. Petr Ryšávka, Ph.D., molecular biologist and probiotics expert
2. PROBIOTIC BIOFILM ON CARRIER SURFACE: A NOVEL PROMISING APPLICATION FOR FOOD INDUSTRY, M. GROSSOVA*, P. RYSAVKA and I. MAROVA, Faculty of Chemistry, Department of Food Chemistry and Biotechnology, Brno University of Technology, Purkynova 118, CZ-61200 Brno. Czech Republic, 2017
3. Manach,C., Scalbert,A., Morand, C. 2004, Polyphenols: Food Sources and Biovailability, American Journal of Cilinical Nutrition, 79(5), 5.2004, s.727-47. Available at: https://academic.oup.com/ajcn/article/79/5/727/4690182
4. Afaq,, F., Katiyar, S.K.2011, Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis. Mini-Reviews in Medicinal Chemistry, 11(14), December 2011, s.1200-1215. Available at: https://www.nebi.nlm.nih.gov/pubmed/22070679.
5. Afaq, F., Zaid, M. A. Khan, N., a kol.2009. Protective Effect of Pomegranate-Derived Products on UVB-Mediated Damage in Human Reconstituted Skin. Experimental Dermatology, 18(6), June 2009, s. 553-61. Available at: https://www.nebi.nlm.nih.gov/pubmed/19320737
6. Source: Antibiotics – WikiSkripta
7. Steven R. Gundry, the Longevity Paradox – How to Die Young at a Ripe Old Age, HarperCollins Publishers, USA, 2019
8. Akst, J.2014 Microbes of the Skin. The Scientist, 13.6.2014
9. University of California – San Diego.2018. Beneficial Skin Bacteria Protect Against Skin center. ScienceDaily

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Tento inovativní produkt na kůži taje působením vašeho tělesného tepla, a činí tak z každé masáže opravdový zážitek. Obsahuje výtažky z řas GUAM a směs cenných přírodních vosků, které vyživují pokožku do hloubky, a jejich zpevňující a elastizující účinky jí dodávají celistvost a pevnost. Díky svému vysokému obsahu bambuckého másla a másla cupuaçu je GUAM Inthenso zvláště vhodné pro ty nejsušší a nejvíce dehydratované typy pleti.

Active ingredients in one capsule: mg /kap. % DRHP*
Bifidobacterium lactis HN019 biofilm Lactobacillus rhamnosus HN001 biofilm 10 x 109 CFU**   –      
Olive, pomegranate, grapefruit, orange, blueberry and green tea extract (polyphenols 51%) 100 mg (of which  epigallocatechin-3-gallate: 6 mg)    –
Riboflavin (vit. B2) 1 mg 71,4%
Biotin (vit. B7) 25 ug 50%
*Reference Daily Intake  **CFU – colony-forming unit at production exit control Ingredients:  Soluble glucose fibre (glucofibre – prebiotic), inulin (prebiotic) , extract from olives, pomegranate, grapefruit, orange, blueberries and green tea (polyphenols 51%), probiotic cultures in the form of biofilm ( Bifidobacterium lactis HN019 biofilm, Lactobacillus rhamnosus HN001 biofilm ), glucomannan (konjac mannan), riboflavin (vitamin B2), biotin (vitamin B7), added substances: filler (hydroxypropyl methylcellulose), anti-caking agent (magnesium salts of fatty acids), mixed component: capsule composition (hydroxypropyl methylcellulose, gellan gum)

3. Uvedená denní sazba je platná v případě zvýhodněného členství v rámci NYADERM BEAUTY CLUB, zvolené varianty časově neomezeného předplatného a odběru minimálně 4 ks NYADERM® Anti-aging Drink během kalendářního roku. Ceny jsou uvedeny včetně DPH (15%) a příslušných poplatků. Neobsahují ale poplatky za doručení (není-li uvedeno jinak).

1. V závislosti na výsledcích klinických studií patentovaných složek obsažených v přípravku NYADERM® Anti-aging Drink v množství odpovídajícím provedeným klinickým studiím.

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