Hair
Probio

World news: The first 4th generation probiotics for hair

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THE FIRST 4TH
GENERATION PROBIOTICS
 FOR HAIR

What affects both gut and hair health?

Are you interested in the causes of excessive hair loss in women and men (alopecia), slow hair growth or why your hair lacks volume and doesn’t look healthy? The biggest threats to a healthy gut microbiome include stress, taking antibiotics or medications, and a poor diet. The absence of probiotic products and excessive use of hair products reduce the quality and diversity of the microbiome in the gut (dysbiosis) as well as on skin and hair.1a

IT ALL STARTS AT THE ROOTS

A dysbiotic (imbalanced) microbiome is unable to perform the functions necessary for healthy maintenance of the hair cycle, such as nutrient supply, vitamin synthesis and immune system regulation 1a. Over the long term, dysbiosis leads to impaired function and contributes to the development of many health problems, including hair loss (1b, 1c).

VISIBLE RESULTS<span class="desktop-break"
AFTER TWO MONTHS

Nyaderm® Hair ProBio is a dietary supplement that comes in the form of vegan-friendly enterosolvent capsules. It contains a unique combination of clinically proven probiotics which reflects the latest scientific findings regarding the relationship between the microbiome and hair – including the beneficial effects of natural substances on the health of the hair shaft.
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EXPERT OPINION

„Research has confirmed the link between gut permeability and hair growth. Increasing gut permeability exposes hair follicles to more damage. Poor conversion and absorption of nutrients due to a dysfunctional gut disrupts the metabolic processes involved in hair synthesis and reduces the functionality of the dermal papilla.”

RNDr. Petr Ryšávka, Ph.D

Gut-hair Axis

The gut-hair axis is a relatively new term that refers to the connection between the gut and the hair. Although it may seem strange at first glance, a number of clinical studies point to a close connection between the gut microbiome and hair – particularly the skin, where hair follicles are located. This is evidenced by cases of alopecia (hair loss), which are often the result of an autoimmune reaction. In some cases, simply stabilizing the gut microbiome is enough to quiet the autoimmune reaction against the hair follicles.1

Unique composition
and technology

Contains
5 carefully selected
4th generation
probiotic strains for
 hair

Including
 Parabiotic
from fermented
rhodiola

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how does hair ProBio help you hair?

Nyaderm® Hair ProBio brings a revolutionary solution in comprehensive hair care from within, at any age and for both genders. What does the comprehensive dietary supplement solve?

Posiluje řídnoucí vlasy zevnitř

Obnovuje růst vlasových kořínků

Omezuje vypadávání vlasů

Podporuje plnější a hustější vlasy

Redukuje stres

Snižuje zánět v těle

Normalizuje činnost mazových žláz

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Everithing for hair that shines with health

Discover the active ingredients of Hair ProBio, including the power of fermented paraprobiotics.

4th generation hair probiotics

Within our special formulation there is a combination of five probiotic strains in biofilm form, which has been shown to…
Read more >

Fermented rhodiola

The effect of rhodiola was tested in a rigorous clinical study, which confirmed the positive effect of this plant on the growth and recovery of…
Read more >

Spermidine

Spermidine is a natural amine that can play an important role in cell survival. Clinical data provide direct…
Read more >
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The best hair cair? protection

From childhood onwards, hair undergoes a constant process of growth, death and replacement. The number of hair follicles from which hair grows is largely determined by genetics and a person has the same number for life. There are approximately one hundred thousand hairs on the head and the daily increase in hair length is three to four tenths of a millimeter.

Hair renewal in humans is gradual and continuous. However, as the depth of the hair follicle shortens, the supply of nutrients deteriorates, causing a gradual deterioration in hair quality. Newly grown hair tends to be thinner and weaker. This process can be prevented by using Hair ProBio, which promotes hair growth and also serves as a prevention of premature thinning and hair loss.
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Studies and citations

All studies and citation referenced.

Studies and citations

4th generation hair probiotics

Within our formula is a combination of 5 probiotic strains, including an organic plant-based specimen which has been proven to reduce inflammation in the body and calm stress, the biggest cause of hair loss and poor hair quality. It is also involved in regulating the immune system, which can interfere with skin and hair health as well. Systemic inflammation is closely linked to hair loss and alopecia, the result of the body’s own immune system attacking healthy tissue.

Lactobacilius reuterii
LR200 fixed biofilm

The use of this culture showed increased hair quality in a lab model, providing them with thick and shiny hair. One of the reasons for this is the interaction with IL-10 and IL-17, or the reduction of their production. Hair loss is, in many cases, the result of an inflammatory process, which can be stopped by regulating pro-inflammatory interleukins. In humans, Lactobacillus reuterii has also been shown to attenuate the expression of the pro-inflammatory gut cytokines TNF-α and subsequently reduce the inflammatory cascade throughout the body(1d, 1e).IL-17 is involved in various inflammatory diseases by inducing chemokines that recruit neutrophils and monocytes (1d, 1f). It is thought that elevated IL-17 interferes with scalp growth and therefore becomes a major target for anti-inflammatory therapies.

Lactobacilius helveticus
LH200 fixed biofilm

Daily administration of this culture for 30 days reduced urinary free cortisol evacuated in response to daily stressful situations in humans. This contributed to the balance and control of the stress hormone in the hair follicle (1h).

Lactobacilius rhamnosus
GG450 fixed biofilm

This culture has been shown to have system-wide anti-inflammatory effects and plays an important role in protecting the intestinal lining. At the cellular level, it stimulates the production of cytoprotective shock proteins, prevents apoptosis and promotes cell growth, which is also closely linked to hair growth (1g).

Lactobacilius rhamnosus LB21 fixed
biofilm a Lactobacillus Rhamnosus SP1 fixed biofilm

These compounds work together to normalize the activity of sebocytes. Excessive activity leads to increased production of sebum and may negatively affect hair growth and appearance. Conversely, low sebocyte activity leads to insufficient sebum production and thus negatively affects hair strength and elasticity, and results in a dull appearance with low hair shine(2).

These compounds have been shown to increase the sensitivity of cells to IGF 1 (insulin-like growth factor-1) and are also involved in the regulation of lipogenesis (2).

Insulin-like growth factor-1 (IGF-1) plays a key role in the regulation of the hair cycle, including control of hair shaft differentiation and tissue remodeling, and serves as a key regulator of mitogenic and morphogenetic processes during hair follicle development. As such, IGF-1 has emerged as a promising therapeutic target for hair loss conditions, including AGA and alopecia areata (2).

Fermented
Rhodiola

The effect of rhodiola was tested in a rigorous clinical study, which confirmed the positive effect of this plant on hair growth and renewal – especially in women suffering from hair thinning. Fermenting the rhodiola increases the bioavailability and availability of isoflavones and thus their effectiveness.

Fermented rhodiola contains paraprobiotics with similar health benefits to live probiotic strains. Due to activation by bacteria, a much lower daily dose is required. The rhodiola plant contains many other intelligent substances (flavonoids) that are highly beneficial to the body. The synergy of the plant’s secondary metabolites in their most absorbable form is vital for health.(3)

Fermented
Gynostemma
pentaphyllum

Gynostemma, a natural adaptogen, is a great helper in the fight against stress, which often causes hair loss. Stress affects not only our nervous system, but the whole body, and its most well-known product is cortisol. Evolution gave us this hormone to prepare us for high performance and quick reactions, but with prolonged stress, such as we experience at work or in interpersonal conflicts, cortisol can have a negative effect. Elevated cortisol levels lead to the risk of diabetes, weakened immunity, loss of skin elasticity and damage to hair roots. Gynostemma counteracts these effects of stress, supports the health of the cardiovascular system, helps regulate blood pressure and blood sugar, and also protects against infections due to its antiviral, antifungal and antibacterial properties. In addition, it is one of nature’s best antioxidants and promotes weight loss, contributing to overall vitality and health.(2)

Spermidin

Spermidine is a natural amine that may play an important role in cell survival. Clinically relevant data provide direct evidence that spermidine is a potent stimulator of human hair growth and a previously unknown modulator of human epithelial stem cell regeneration. Fluorimetric assays revealed that spermidine dose-dependently stimulates the production of primary human epidermal keratinocytes, which are directly related to hair formation.(4)

Vitamin D

This vitamin contributes to the maintenance of normal immune system function. A healthy and functional immunity system always reflects in the health and radiance of hair and skin.

Copper

Copper also plays an important role in hair care. It contributes to normal pigmentation of hair and skin.

L-Cystein

L-cysteine has a direct effect on the formation of keratin, which is an integral part of our hair and nails. Among other things, it acts as a powerful antioxidant.

Biotin

Biotin contributes to the maintenance of normal hair, skin and mucous membranes. Biotin, also called vitamin B7 or vitamin H, is considered a beauty product.

Zinc

Zinc contributes to the maintenance of normal hair, nails and skin. People most often associate zinc with hair.

Dissolved
corn
fibre

This substance, which dissolves easily in water, is known for its ability to support a healthy gut flora and digestive system. Due to its solubility, it is also well-tolerated in the digestive system and provides the necessary nutrition for the beneficial bacteria in the intestines.
Studie a citace
1. Kogan, S., & Marshall, T. (2019, August 28). Exploring the connection between gut health and hair. Practical Dermatology. https://practicaldermatology.com/issues/supplements/explori ng-the-connection-between-gut-health-and-hair/23089/

a) Langdon, A., Crook, N., & Dantas, G. (2016). The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome medicine, 8, 1-16.
b) Francino, M. (2016). Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances. Frontiers in microbiology, 6, 164577.

c) Guo, Y., Qi, Y., Yang, X., Zhao, L., Wen, S., Liu, Y., & Tang, L. (2016). Association between polycystic ovary syndrome and gut microbiota. PloS one, 11(4), e0153196.

d) Levkovich, T., Poutahidis, T., Smillie, C., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., ... & Erdman, S. E. (2013). Probiotic bacteria induce a ‘glow of health’. PloS one, 8(1), e53867.
e) del Campo, R., Garriga, M., Pérez-Aragón, A., Guallarte, P., Lamas, A., Máiz, L., ... & Suárez, L. (2014). Improvement of digestive health and reduction in proteobacterial populations in the gut microbiota of cystic fibrosis patients using a Lactobacillus reuteri probiotic preparation: a double blind prospective study. Journal of Cystic Fibrosis, 13(6), 716-722.

f) Kober, M. M., & Bowe, W. P. (2015). The effect of probiotics on immune regulation, acne, and photoaging. International journal of women's dermatology, 1(2), 85-89.

g) Yan, F., & Polk, D. B. (2006). Probiotics as functional food in the treatment of diarrhea. Current Opinion in Clinical Nutrition & Metabolic Care, 9(6), 717-721.

h) Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., ... & Cazaubiel, J. M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755-764.
2. RNDr. Petr Ryšávka, Ph.D., molekulární biolog a expert na probiotika
3. Glynis A. (2012). A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. The Journal of clinical and aesthetic dermatology, 5(11), 28–34.
4. Ramot, Y., Tiede, S., Bíró, T., Abu Bakar, M. H., Sugawara, K., Philpott, M. P., Harrison, W., Pietilä, M., & Paus, R. (2011). Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PloS one, 6(7), e22564. https://doi.org/10.1371/journal.pone.0022564
Studie a citace
1. Kogan, S., & Marshall, T. (2019, August 28). Exploring the connection between gut health and hair. Practical Dermatology. https://practicaldermatology.com/issues/supplements/explori ng-the-connection-between-gut-health-and-hair/23089/

a) Langdon, A., Crook, N., & Dantas, G. (2016). The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome medicine, 8, 1-16.
b) Francino, M. (2016). Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances. Frontiers in microbiology, 6, 164577.

c) Guo, Y., Qi, Y., Yang, X., Zhao, L., Wen, S., Liu, Y., & Tang, L. (2016). Association between polycystic ovary syndrome and gut microbiota. PloS one, 11(4), e0153196.

d) Levkovich, T., Poutahidis, T., Smillie, C., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., ... & Erdman, S. E. (2013). Probiotic bacteria induce a ‘glow of health’. PloS one, 8(1), e53867.
e) del Campo, R., Garriga, M., Pérez-Aragón, A., Guallarte, P., Lamas, A., Máiz, L., ... & Suárez, L. (2014). Improvement of digestive health and reduction in proteobacterial populations in the gut microbiota of cystic fibrosis patients using a Lactobacillus reuteri probiotic preparation: a double blind prospective study. Journal of Cystic Fibrosis, 13(6), 716-722.

f) Kober, M. M., & Bowe, W. P. (2015). The effect of probiotics on immune regulation, acne, and photoaging. International journal of women's dermatology, 1(2), 85-89.

g) Yan, F., & Polk, D. B. (2006). Probiotics as functional food in the treatment of diarrhea. Current Opinion in Clinical Nutrition & Metabolic Care, 9(6), 717-721.

h) Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., ... & Cazaubiel, J. M. (2011). Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. British Journal of Nutrition, 105(5), 755-764.
2. RNDr. Petr Ryšávka, Ph.D., molekulární biolog a expert na probiotika
3. Glynis A. (2012). A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. The Journal of clinical and aesthetic dermatology, 5(11), 28–34.
4. Ramot, Y., Tiede, S., Bíró, T., Abu Bakar, M. H., Sugawara, K., Philpott, M. P., Harrison, W., Pietilä, M., & Paus, R. (2011). Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PloS one, 6(7), e22564. https://doi.org/10.1371/journal.pone.0022564

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Active ingredients in one capsule: mg /kap. % DRHP*
Bifidobacterium lactis HN019 biofilm Lactobacillus rhamnosus HN001 biofilm 10 x 109 CFU**   –      
Olive, pomegranate, grapefruit, orange, blueberry and green tea extract (polyphenols 51%) 100 mg (of which  epigallocatechin-3-gallate: 6 mg)    –
Riboflavin (vit. B2) 1 mg 71,4%
Biotin (vit. B7) 25 ug 50%
*Reference Daily Intake  **CFU – colony-forming unit at production exit control Ingredients:  Soluble glucose fibre (glucofibre – prebiotic), inulin (prebiotic) , extract from olives, pomegranate, grapefruit, orange, blueberries and green tea (polyphenols 51%), probiotic cultures in the form of biofilm ( Bifidobacterium lactis HN019 biofilm, Lactobacillus rhamnosus HN001 biofilm ), glucomannan (konjac mannan), riboflavin (vitamin B2), biotin (vitamin B7), added substances: filler (hydroxypropyl methylcellulose), anti-caking agent (magnesium salts of fatty acids), mixed component: capsule composition (hydroxypropyl methylcellulose, gellan gum)

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